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The prosthesis grows with the patient

13.02.2001

Scientists from the Cryolife medical corporation in Atlanta (USA) and German doctors are now developing a prosthetic heart valve for children, which is expected to grow with the patient.

If such a valve is implanted in a child, there will be no need for subsequent operations to replace it with a larger valve in a growing heart. Moreover, this prosthesis is gradually overgrown with host cells and becomes completely its own.

The starting material is a porcine heart valve, chemically freed from all cells that can cause a rejection reaction or are capable of carrying any porcine viruses that are dangerous to humans. There remains a pure collagen base - and the structure of collagen, this connective tissue protein, is basically the same in all mammals, and the immune system does not react to it. American doctors transplant patients with a pure collagen base of the valve, which is then overgrown with heart cells in the body.

The Germans prefer to populate the collagen skeleton with the cells of the inner lining of the patient's blood vessels even before transplantation and hold the valve in the incubator for a while so that these cells multiply. The Americans first tested their product on sheep, and now there are already six people living in Australia with growing valves.

The German prosthesis has not yet passed the stage of animal testing, the first human transplants will be made this year.

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