Molecular scissors will remove the AIDS virus. Free Technical Library News

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Molecular scissors will remove the AIDS virus

15.02.2008

Employees of the Institute of Experimental Virology and Immunology in Hamburg (Germany) have created an enzyme using genetic engineering methods that can search for the AIDS virus gene in human DNA and cut it out.

The AIDS virus, like other viruses, inserts its genome into the nucleus of the cells it infects and causes them to make copies of themselves. There are enzymes, the so-called recombinases, that can recognize and cut out certain sections of DNA. Taking one such recombinase, naturally tuned to a DNA sequence remotely similar to the DNA of a virus, biologists gradually changed the enzyme so that it began to act specifically on the AIDS gene. The excised gene is decomposed by the cell, and its remnants are removed.

Experiments conducted on a culture of human cells infected with the AIDS virus proved the effectiveness of the new enzyme. But it is not yet clear how soon it will be able to be used to treat people: a way to deliver recombinase to virus-infected cells remains to be found.

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