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Rheumatics and athletes - in the cold

26.12.2000

A strange method of treating arthritis and rheumatism is used in the department of rheumatology of the clinic in the German city of Sentenhorst. This is the stay of an almost naked person in a refrigerator with a temperature of minus 110-120 degrees Celsius.

A session lasting two to three minutes for some time relieves pain in the joints. The patient enters the cell in gloves and with a mask on his face, so as not to freeze his fingers and nose. The skin on the body is cooled down to plus two degrees Celsius. Between "refrigeration" courses of treatment, it is possible to reduce the doses of usually taken drugs.

Some doctors expressed concern that a sudden cooling could cause a heart attack, but the head of the clinic replies that a heart check is carried out before treatment and there have been no such problems in 15 years of using the method.

Sports doctors became interested in an unusual method of treatment. It turned out that a short-term (up to three minutes) stay at an ultra-low temperature acts on the muscles like a good massage, improves their blood supply and increases the athlete's endurance by 20 percent.

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First biological pacemaker cells grown 22.12.2016

Scientists from the MacEwen Center for Regenerative Medicine at Heath University (USA), led by postdoc Stephanie Protze, have for the first time grown working heart pacemakers from stem cells in the laboratory.

We are talking about cells that generate impulses that determine the heart rate. These cells are concentrated in a special area of the heart muscle. When they fail to do their job, a person needs a mechanical pacemaker.

The method builds on previous work by the same research team that has worked out in detail which substances (signaling molecules) given in strictly defined amounts in a strictly defined order can turn a mammalian stem cell into a pacemaker cell.

"We're replicating human biology in a petri dish," explained Dr. Gordon Keller, director of the McEwen Center and one of the paper's co-authors. "We're replicating the path nature takes to make these cells."

Cells obtained in vitro - pacemakers have already been transplanted into the heart of laboratory mice and work normally there.

The significance of this work cannot be overestimated: thanks to the achievements of Protze, Keller and their colleagues, in the future it may be possible to grow biological pacemakers in the laboratory that will be much better integrated into the human body and work more efficiently than artificial ones.

However, scientists say that clinical trials of the new method in humans are still far away - it will take at least five to ten years for scientists to work well enough on mice.

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