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Bloodhound Mouse

12.09.2004

Biologists from the University of Florida in Tallahassee (USA) have bred a breed of mice, the sense of smell in which is significantly enhanced compared to ordinary mice. Oddly enough, for this it was not necessary to add a gene to mice, but to eliminate one of the existing ones.

The knocked-out gene produces a protein called Kv1.3, which is involved in the formation of "valves" in the nerve cell membrane that control the flow of potassium ions in and out of the cell. And the rate of flow of potassium ions depends on how quickly and actively the nerve cell reacts to stimuli.

The Kv1.3 protein is present in the cells of the olfactory bulbs, and the scientists thought that turning off its gene would lead to a weakening of the mouse's sense of smell. But it turned out that the sense of smell, on the contrary, is enhanced by 1000-10000 times. No other anomalies have been found in the new breed of rodents.

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