A drug to stimulate the growth of new teeth. Free Technical Library News

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A drug to stimulate the growth of new teeth

29.09.2023

A team of Japanese scientists in collaboration with pharmaceutical startup Toregem Biopharma Co. is actively working to develop the world's first drug that can stimulate the growth of new teeth in humans.

According to the researchers, most people, with the exception of baby and permanent teeth, have so-called tooth germs that can potentially develop into new teeth. However, these rudiments usually do not develop and disappear over time.

In light of this problem, experts have begun to create a drug containing antibodies that block a protein that slows down tooth growth. This drug actively affects tooth germs, promoting their active development.

Toregem Biopharma Co., which received funding from Kyoto University, is expected to begin clinical trials of the drug in adults around July 2024.

In addition, the researchers plan to conduct clinical trials of the drug starting in 2025 in children ages 2 to 6 years old with anodontia, which means that some or all of their permanent teeth are missing from birth.

Children will be given one dose of the drug to stimulate tooth growth. The possibility of using this drug in the future for adults suffering from tooth loss due to caries is also being discussed.

The researchers plan to bring the drug to market around 2030. In 2018, this team was able to successfully grow new teeth in mice. Also in the same year, specialists were able to apply the drug to ferrets, which have both primary and permanent teeth similar to humans, and to achieve the growth of new teeth in these mammals.

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