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Bioink that triggers tissue regeneration

12.09.2023

Scientists have presented innovative bioinks that can improve the growth and recovery of muscle tissue created using 3D printers.

Muscle is a complex environment where different cell types coexist in a single system. Muscle damage due to injury, disease, or surgery is a challenging medical problem. Today, doctors often take healthy muscles from other parts of the patient's body to replace damaged ones. But this method is ineffective and comes with a number of problems, including damage to the donor area and difficulty restoring muscle function.

A team of scientists from the Terasaki Institute for Biomedical Innovation in Los Angeles has developed a unique bioink that provides a new approach to solving this difficult problem. These bioinks were designed to recreate the natural muscle growth process, the main component of which is the hormone insulin-like growth factor-1 (IGF-1), which plays an important role in the growth and development of muscles and tissues.

The special composition of the bioink includes a body-compatible gel, myoblast cells and microscopic particles coated with IGF-1. These particles gradually release the hormone, promoting the growth of muscle tissue. Comparative studies have shown that tissues created with IGF-1 have better structure, are more mature and contractile.

Scientists conducted experiments by implanting 3D-printed pieces of muscle tissue into mice. The results are encouraging: after a month and a half, mice with muscle tissue enhanced by IGF-1 showed better regeneration. The study points to the potential of new bioinks to accurately recreate natural muscle tissue.

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