The biodegradable implant cools the nerves and relieves pain. Free Technical Library News

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Biodegradable implant cools nerves and relieves pain

10.07.2022

American researchers have presented a biodegradable implant in the form of a nerve tape, which, thanks to the cold, blocks the transmission of pain signals.

Tests on rats have shown that the implant successfully cools the nerve to 10 degrees Celsius, reducing sensitivity to mechanical irritation and gradually dissolves safely in the body.

The application of ice or other cold to the damaged area has long been known and used to reduce pain. It works, in part, by reducing the speed and magnitude of the nerve impulse, that is, preventing the transmission of pain signals from the peripheral nerves to the brain. This usually occurs at temperatures below 15 degrees Celsius, but prolonged local exposure to cold can cause tissue damage.

In an effort to maximize the effect of a pain relief method with a minimum of unwanted reactions, Northwestern University scientists and colleagues have developed a cooling nerve implant that blocks the transmission of pain signals from an injured part of the body.

The invention is in the form of a tape only five millimeters wide, which is designed to wrap one end of the nerve during surgery, while the other end is connected when leaving the body with a small pump.

The base is made from a flexible, biocompatible polymer that forms a microfluidic system of channels that controllably pump perfluoropentane coolant and nitrogen gas. When these two chemicals are combined in the duct system, the perfluoropentane evaporates, creating a cooling effect. The tape also contains an electronic temperature measurement system for its control.

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