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Molecular electronic chip

03.02.2022

Roswell Biotechnologies announced the completion of the development and successful testing of a new generation biosensor chip. The sensor is able to detect single molecules, enzyme activity, and even monitor the process of DNA synthesis in real time. This possibility not only simplifies the decoding of the biomaterial, but also opens the way to devices for recording data on DNA carriers.

Scientists have been developing biosensor chips for a long time, but the COVID-19 pandemic has significantly pushed the search for solutions. Roswell Biotechnologies, together with colleagues from the Belgian center Imec, have gone from a project to a ready-made solution in less than two years. The advanced 16-pixel silicon-based sensor is capable of operating at 1000 frames per second, enabling instant diagnosis of viruses, drugs, DNA sequencing, protein analysis, and more that used to cost a lot of time and money.

According to the developers, they have created the first ever molecular sensor, which paves the way for the launch of Moore's law in the field of biodetection. The array can be scaled up to new values ​​of density and detection accuracy, increasing the speed and quality of biomaterial studies. The elementary detection device is a special molecule in each pixel of the sensor, which captures a biomaterial sample and makes it possible to accurately determine its composition.

Roswell's proposed platform consists of a programmable semiconductor chip with a scalable sensor array architecture. The chip also includes multichannel ADCs for converting information into digital form for its further analysis by machine learning tools. The elementary pixel of the sensor consists of two nanoelectrodes with a gap of 20 nm. To assess the biomaterial, a molecular thread of active biological material, such as a synthetic alpha-helical protein, is suspended between the gaps. Such a protein captures a biomaterial sample for further testing.

An electric current is passed through the electrodes and the molecular thread. The current strength will depend on the resistance of the circuit and will accurately indicate the target biomaterial captured by the sensor. The accuracy of material determination is so high that the technology can be used as a reader for writing data on DNA. Sensor pixels can carry built-in DNA polymerase enzymes, which allows direct electrical observation of the action of this enzyme as it copies a DNA fragment element by element. Modern diagnostics does not allow this, working with DNA only through indirect measurements. This has the potential to revolutionize medicine and biological research in many related areas: in paleontology, forensics, agriculture, and much more.

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Random news from the Archive

Cocoa with flavonoids makes people smarter 18.10.2023

Increasing the consumption of flavonoids, which are part of cocoa beans, has a positive effect on human cognitive functions. American scientists came to this conclusion.

Cocoa beans contain many beneficial substances, including flavonoids. Studies have shown that increasing the concentration of these substances can speed up human thought processes even with high concentrations of carbon dioxide in the air.

Flavonoids are substances present in plants that play an important role in the human body. They have antioxidant activity, strengthen blood vessels, slow down blood clotting and improve the elasticity of red blood cells. Flavanols, a subgroup of flavonoids, are present in cocoa, grapes, apples, tea, berries and other foods. Although they are known to have beneficial effects on heart and vascular health, their effects on the brain require more research.

This scientific study was the first to confirm the link between flavonoid consumption and improved cognitive performance. As part of the work, scientists used a drink made from cocoa beans as a source of these compounds. However, the researchers note that the results also apply to other foods, such as fruits and green tea.

In the study, 18 healthy men aged 18 to 40 underwent a standard cerebral blood flow test. Under conditions of hypercapnia caused by inhaling air containing high levels of carbon dioxide, participants were given cognitive tests to assess brain activity.

The results showed that participants who consumed the flavanol-enriched drink had higher blood oxygen levels during hypercapnia. The concentration of oxygen in brain tissue increased three times compared to a regular drink. Also, after consuming cocoa with flavonoids, participants completed cognitive tests 11% faster.

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