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Lifespan biomarker found

22.12.2021

American scientists have found that the rate of accumulation of genetic mutations can predict how many years a person will live. In women, this method also allows you to predict the period of fertility.

It has long been known that DNA damage occurs constantly throughout life, but the body has repair mechanisms that prevent the accumulation of harmful mutations. Over time, these mechanisms become less efficient, so, for example, older parents tend to pass on more genetic mutations to their offspring through the germline - egg and sperm.

Biologists from the University of Utah and the University of Louisville have suggested that the rate at which a person acquires DNA mutations can serve as a biomarker of aging and can predict lifespan even in young people, as well as fertility in women.

The basis for the study was the databank of the Center for the Study of Human Polymorphism, an international genetic research institute in Paris, which plays a key role in many major studies that contribute to the modern understanding of human genetics.

The sample included 41 families, each of three generations. The authors analyzed blood DNA sequences in triplets of 61 pairs of first-generation grandparents and one of their children.

So, they compared the mutations found in the DNA of representatives of both generations, and were able to determine how much each of their parents had accumulated in the egg or sperm at the time of the child's conception, and then calculated the number of mutations and the rate of their accumulation for the second generation.

Since this study is retrospective, scientists were able to compare life expectancy with the number of accumulated mutations not only for the older, but also for the middle generation.

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